im wondering if you have a missing or broken physx system software.
Please send me your skyline.log from the Win32_Release folder

and the Skyline_techsupport.txt
as it sounds like physx has not initialised correctly on engine boot.
Edit: We used to get this because physx updated that system software to be compatible with physx3 and dropped support of physx 2.8 which is what we use. You may need to install:
to get it physx running which may require an uninstall of the latest physx system software first, then install this one and then upgrade to the latest..